Stromal-cell-derived factor 1 prevents the emergence of the syncytium-inducing phenotype of HIV-1 in vivo

• Published in: AIDS (London) Vol. 15; no. 14; pp. 1890 - 1892
• Main Authors: Llano, Anuska, Barretina, Jordi, Blanco, Julià, Gutiérrez, Arantxa, Clotet, Bonaventura, Esté, José A.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 28.09.2001
• Subjects: Biological and medical sciences; Chemokine CXCL12; Chemokines, CXC - blood; Chemokines, CXC - physiology; Giant Cells; HIV Infections - blood; HIV Infections - pathology; HIV Infections - virology; HIV-1 - classification; HIV-1 - physiology; Human immunodeficiency virus 1; Human viral diseases; Humans; Infectious diseases; Medical sciences; Phenotype; SDF-1 protein; stromal cell-derived factor 1; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; HIV-1 virus; Pathogenesis; Genetic variant; Retroviridae; AIDS; Immune deficiency; Lentivirus; Blood plasma; Infection; Virus; Stromal cell derived factor 1; In vivo; Syncytium; Phenotype; Viral disease; Human immunodeficiency virus
• ISSN: 0269-9370
• DOI: 10.1097/00002030-200109280-00023

In a correlative study, the mean plasma level of the chemokine stromal-cell-derived factor 1 (SDF-1) was lower in subjects with syncytium-inducing (SI) than in subjects with non-syncytium-inducing (NSI) HIV isolates, regardless of the CD4 cell count or when compared with HIV-negative individuals. Individuals with high SDF-1 had an 81% probability of having an NSI virus phenotype compared with individuals with lower SDF-1. Increased expression of SDF-1 may help explain why the more pathogenic SI HIV-1 variants do not appear in some individuals.