Determination of Mesothelin Levels in Pleural Effusion Does Not Help Predict Survival of Patients With Malignant Pleural Mesothelioma

• Published in: Anticancer research Vol. 39; no. 9; pp. 5219 - 5223
• Main Authors: Fontana, Vincenzo, Pistillo, Maria Pia, Vigani, Antonella, Canessa, Pier Aldo, Berisso, Giovanni, Giannoni, Ugo, Ferro, Paola, Franceschini, Maria Cristiana, Carosio, Roberta, Tonarelli, Marika, Rossi, Cristiana, Dessanti, Paolo, Roncella, Silvio
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.09.2019
• Subjects: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers, Tumor; Categories; Enzyme-linked immunosorbent assay; Female; GPI-Linked Proteins - metabolism; Humans; Level (quantity); Lung Neoplasms - complications; Lung Neoplasms - diagnosis; Lung Neoplasms - mortality; Lung Neoplasms - therapy; Male; Mesothelioma; Mesothelioma - complications; Mesothelioma - diagnosis; Mesothelioma - mortality; Mesothelioma - therapy; Mesothelioma, Malignant; Middle Aged; Patients; Pleural effusion; Pleural Effusion, Malignant - diagnosis; Pleural Effusion, Malignant - etiology; Pleural Effusion, Malignant - metabolism; Pleural Effusion, Malignant - therapy; Pleural Neoplasms - complications; Pleural Neoplasms - diagnosis; Pleural Neoplasms - mortality; Pleural Neoplasms - therapy; Prognosis; ROC Curve; Statistical analysis; Survival; Treatment Outcome; Mesothelioma; pleural effusion; prognosis; mesothelin
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.13719

This study evaluated the prognostic value of soluble mesothelin-related protein (SMRP) levels in pleural effusions (PE) from patients with pleural mesothelioma (MPM). SMRP level in PE was tested using an enzyme-linked immunosorbent assay (ELISA) in 109 patients with MPM at diagnosis before any treatment. The Kaplan-Meier method and the Cox regression were applied to compare overall survival probabilities across tertile categories of SMRP level. No significant differences in Kaplan-Meier overall survival probabilities among the SMRP categories were found. A statistically non-significant trend for increased death rate ratio (RR) was computed (p=0.327) when the higher (>46.5 nM, RR=1.38) and intermediate (8.5-46.5 nM, RR=1.18) SMRP categories were compared to the lower category (<8.5 nM, RR=1.00). Cox regression modelling including a restricted cubic spline showed a moderately rising non-linear trend in death rate. The SMRP level in PE does not appear to have prognostic significance and its detection is not recommended in routine clinical management of patients with MPM.