Expression of Genes Encoding Cell Motility Proteins during Progression of Head and Neck Squamous Cell Carcinoma

• Published in: Bulletin of experimental biology and medicine Vol. 166; no. 2; pp. 250 - 252
• Main Authors: Kakurina, G. V., Kondakova, I. V., Spirina, L. V., Kolegova, E. S., Shashova, E. E., Cheremisina, O. V., Novikov, V. A., Choinzonov, E. L.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2018; Springer Nature B.V
• Subjects: Actin; Biomedical and Life Sciences; Biomedicine; Biopsy; Calpain - genetics; Calpain - metabolism; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Biology; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell Movement - genetics; Cofilin 1 - genetics; Cofilin 1 - metabolism; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; Disease Progression; Epithelium; Female; Gene expression; Gene Expression Regulation, Neoplastic; Head & neck cancer; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans; Hypopharynx; Hypopharynx - metabolism; Hypopharynx - pathology; Internal Medicine; Laboratory Medicine; Larynx; Larynx - metabolism; Larynx - pathology; Male; Mesenchyme; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Middle Aged; Motility; mRNA; Pathology; Profilins - genetics; Profilins - metabolism; Proteins; rho GTP-Binding Proteins - genetics; rho GTP-Binding Proteins - metabolism; Signal Transduction; Snail Family Transcription Factors - genetics; Snail Family Transcription Factors - metabolism; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; Vimentin - genetics; Vimentin - metabolism; chronic hyperplastic laryngitis; actin-binding proteins; mesenchymal and amoeboid types of cell motility; locomotion; head and neck squamous cell carcinoma
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-018-4325-1

The model of head and neck squamous cell carcinoma (HNSCC) was used to study the expression of genes encoding actin-binding proteins depending on the type of cell motility. The expression of SNAIL1 and CAPN2 mRNA in HNSCC tissue was higher than in specimens of dysplastic epithelium of the larynx and hypopharynx, which can be explained by activation of mesenchymal and amoeboid types of cell motility. In biopsy material of HNSCC patients with T1-2N0M0, expression of genes responsible for actin-binding proteins differed from that of patients with pretumor pathology of the larynx and hypopharynx: expression of FSCN was lower, while expressions of EZR and CAP1 were higher. The data attest that progression of HNSCC is associated with activation of both types of cell motility and with the changes in the expression of mRNA encoding cell motility proteins.