Quinazolinone-based hybrids with diverse biological activities A mini-review

Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligand...

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Published inJournal of research in medical sciences Vol. 27; no. 1; p. 68
Main Authors Rezaeinasab, Rezvan, Jafari, Elham, Khodarahmi, Ghadamali
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer - Medknow 01.01.2022
Wolters Kluwer Medknow Publications
Subjects
biological activities
hybrid
quinazoline
quinazolinone
Review
synthesis
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Abstract Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Therefore, due to the importance of the biological activities of quinazolinones for the development of new therapeutic agents, this review emphasizes current findings on various quinazolinone-based hybrids in medicinal chemistry. Moreover, it highlights the biological activities and structure-activity relationship of these hybrids.
AbstractList Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Therefore, due to the importance of the biological activities of quinazolinones for the development of new therapeutic agents, this review emphasizes current findings on various quinazolinone-based hybrids in medicinal chemistry. Moreover, it highlights the biological activities and structure-activity relationship of these hybrids.
Author Rezaeinasab, Rezvan
Khodarahmi, Ghadamali
Jafari, Elham
AuthorAffiliation 1 Department of Medicinal Chemistry, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Medicinal Chemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
AuthorAffiliation_xml – name: 2 Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
– name: 3 Department of Medicinal Chemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
– name: 1 Department of Medicinal Chemistry, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
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  fullname: Rezaeinasab, Rezvan
– sequence: 2
  givenname: Elham
  surname: Jafari
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  surname: Khodarahmi
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Snippet Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic,...
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SubjectTerms biological activities
hybrid
quinazoline
quinazolinone
Review
synthesis
Subtitle A mini-review
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Title Quinazolinone-based hybrids with diverse biological activities
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Volume 27
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