Quinazolinone-based hybrids with diverse biological activities A mini-review

Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligand...

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Bibliographic Details
Published inJournal of research in medical sciences Vol. 27; no. 1; p. 68
Main Authors Rezaeinasab, Rezvan, Jafari, Elham, Khodarahmi, Ghadamali
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer - Medknow 01.01.2022
Wolters Kluwer Medknow Publications
Subjects
biological activities
hybrid
quinazoline
quinazolinone
Review
synthesis
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Summary:Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Therefore, due to the importance of the biological activities of quinazolinones for the development of new therapeutic agents, this review emphasizes current findings on various quinazolinone-based hybrids in medicinal chemistry. Moreover, it highlights the biological activities and structure-activity relationship of these hybrids.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1735-1995
1735-7136
DOI:10.4103/jrms.jrms_1025_21