Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA
Nasopharyngeal carcinoma (NPC) is a malignant tumor that usually occurs in people from Southeast Asia and Southern China. NPC is prone to migration and invasion, leading to poor prognosis. A large number of circular RNAs (circRNAs) exacerbate the process of metastasis in NPC; however, their underlyi...
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Published in | Science China. Life sciences Vol. 65; no. 11; pp. 2233 - 2247 |
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Main Authors | , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Beijing
Science China Press
01.11.2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Nasopharyngeal carcinoma (NPC) is a malignant tumor that usually occurs in people from Southeast Asia and Southern China. NPC is prone to migration and invasion, leading to poor prognosis. A large number of circular RNAs (circRNAs) exacerbate the process of metastasis in NPC; however, their underlying mechanisms remain unclear. We found that the circular RNA
circCCNB1
, encoded by the oncogene
CCNB1
, was downregulated in NPC biopsies and cell lines.
In vitro
assays show that
circCCNB1
inhibits NPC cell migration and invasion. Moreover,
circCCNB1
induces a protein, nuclear factor 90 (NF90), to bind and prolong the half-life of tight junction protein 1 (
TJP1
) mRNA. Upregulation of TJP1 enhances tight junctions between cancer cells and inhibits NPC cell migration and invasion. This study reveals a novel biological function of
circCCNB1
in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and
TJP1
mRNA, and may provide a potential therapeutic target for NPC. |
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ISSN: | 1674-7305 1869-1889 |
DOI: | 10.1007/s11427-021-2089-8 |