Heart rate variability for rapid risk stratification of emergency patients with malignant disease

• Published in: Supportive care in cancer Vol. 26; no. 9; pp. 3289 - 3296
• Main Authors: Boehm, K., Duckheim, M., Mizera, L., Groga-Bada, P., Malek, N., Kreth, F., Gawaz, M., Zuern, C. S., Eick, C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2018; Springer Nature B.V
• Subjects: Aged; Emergency Service, Hospital; Emergency services; Female; Health risk assessment; Heart rate; Heart Rate - physiology; Humans; Male; Medicine; Medicine & Public Health; Mortality; Neoplasms - pathology; Neoplasms - therapy; Nursing; Nursing Research; Oncology; Original Article; Pain Medicine; Palliative care; Prospective Studies; Rehabilitation Medicine; Risk Assessment; Risk prediction; Deceleration capacity; Emergency department; Heart rate variability; Cancer; Malignant diseases
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-018-4144-y

Introduction Neoplasms are the second most common diseases in western countries. Many patients with malignant diseases repeatedly present themselves in the emergency department (ED). Due to limited capacities, appropriate risk stratification strategies for cancer patients have to be developed. This study assesses if deceleration capacity (DC) of heart rate as a parameter of heart rate variability predicts mortality in emergency patients with malignant diseases. Methods Prospectively, 140 adults with different entities of malignant diseases who presented in the medical ED were included. Primary and secondary endpoints were intrahospital mortality and mortality within 180 days, respectively. We calculated DC from short-term ECG readings of the surveillance monitors. Additionally, the Modified Early Warning Score (MEWS) and laboratory parameters such as white blood cells (WBC), lactate dehydrogenase, serum hemoglobin, and serum creatinine were determined. Results The median age of the patients was 65 ± 14 years. 19.3% of the patients died within the hospital stay and 57.9% died within 180 days. DC and WBC were independent predictors of intrahospital death reaching a hazard ratio (HR) of 0.79 (95% confidence interval (CI) 0.63–0.993, p  = 0.043) and of 1.00 (95% CI 1.00–1.00, p  = 0.003), respectively. DC and serum creatinine independently predicted death within 180 days (HR 0.90, 95% CI 0.82–0.98, p  = 0.023 and HR 1.41, 95% CI 1.05–1.90, p  = 0.018, respectively). Conclusion Deceleration capacity of heart rate is suitable for rapid risk assessment of emergency patients with malignant diseases.