ENZYME LEVELS OF INDIVIDUAL NEURONS IN RELATION TO LIPOFUSCIN CONTENT

By quantitative histochemical methods, activities of (α-naphthyl) acid phosphatase and β-galactosidase, and of malate and lactate dehydrogenase, were measured in individual human anterior horn nerve cell bodies selected for high and low lipofuscin content. No significant differences were found. Howe...

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Bibliographic Details
Published inThe journal of histochemistry and cytochemistry Vol. 18; no. 4; pp. 268 - 270
Main Author HIRSCH, HILDE E
Format Journal Article
LanguageEnglish
Published London, England Histochemical Soc 01.04.1970
SAGE Publications
Subjects
Acid Phosphatase - analysis
Female
Galactosidases - analysis
Histocytochemistry
Humans
Lipids
Lysosomes - enzymology
Malate Dehydrogenase - analysis
Middle Aged
Motor Neurons - enzymology
Pigments, Biological
Spinal Cord
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Summary:By quantitative histochemical methods, activities of (α-naphthyl) acid phosphatase and β-galactosidase, and of malate and lactate dehydrogenase, were measured in individual human anterior horn nerve cell bodies selected for high and low lipofuscin content. No significant differences were found. However, when single neurons were subdivided into pigmented and unpigmented portions, the two lysosomal enzymes were considerably more active, and malate and lactate dehydrogenase less active, in the lipofuscin-rich part of the cell. These results are consistent with the view that lipofuscin granules are derived from lysosomes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1554
1551-5044
DOI:10.1177/18.4.268