Performance Characteristics of the Biograph Vision Quadra PET/CT System with a Long Axial Field of View Using the NEMA NU 2-2018 Standard

• Published in: Journal of Nuclear Medicine Vol. 63; no. 3; pp. 476 - 484
• Main Authors: Prenosil, George A, Sari, Hasan, Fürstner, Markus, Afshar-Oromieh, Ali, Shi, Kuangyu, Rominger, Axel, Hentschel, Michael
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.03.2022
• Subjects: Acceptable noise levels; Computed tomography; Crystals; Data acquisition; Energy resolution; Field of view; Image contrast; Image Processing, Computer-Assisted; Image quality; Lutetium; Noise levels; Organs; Performance evaluation; Phantoms, Imaging; Photomultiplier tubes; Point spread functions; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography - methods; Quality assessment; Scanners; Sensitivity; Spatial discrimination; Spatial resolution; Tomography; Tomography, X-Ray Computed; Vision; Visual field; total-body; acceptance test; long field of view; digital PET; NEMA
• ISSN: 0161-5505; 1535-5667; 2159-662X
• DOI: 10.2967/jnumed.121.261972

Our purpose was to evaluate the performance of the Biograph Vision Quadra PET/CT system. This new system is based on the Biograph Vision 600, using the same silicon photomultiplier-based detectors with 3.2 × 3.2 × 20 mm lutetium-oxoorthosilicate crystals. The 32 detector rings of the Quadra provide a 4-fold larger axial field of view (AFOV) of 106 cm, enabling imaging of major organs in 1 bed position. The physical performance of the scanner was evaluated according to the National Electrical Manufacturers Association NU 2-2018 standard, with additional experiments to characterize energy resolution. Image quality was assessed with foreground-to-background ratios of 4:1 and 8:1. Additionally, a clinical F-FDG PET study was reconstructed with varying frame durations. In all experiments, data were acquired using the maximum ring distance of 322 crystals (MRD 322), whereas image reconstructions could be performed with a maximum ring distance of only 85 crystals (MRD 85). The spatial resolution at full width at half maximum in the radial, tangential, and axial directions was 3.3, 3.4, and 3.8 mm, respectively. The sensitivity was 83 cps/kBq for MRD 85 and 176 cps/kBq for MRD 322. The noise-equivalent count rates (NECRs) at peak were 1,613 kcps for MRD 85 and 2,956 kcps for MRD 322, both at 27.49 kBq/mL. The respective scatter fractions at peak NECR equaled 36% and 37%. The time-of-flight resolution at peak NECR was 228 ps for MRD 85 and 230 ps for MRD 322. Image contrast recovery ranged from 69.6% to 86.9% for 4:1 contrast ratios and from 77.7% to 92.6% for 8:1 contrast ratios reconstructed using point-spread function time of flight with 8 iterations and 5 subsets. Thirty-second frames provided readable lesion detectability and acceptable noise levels in clinical images. The Biograph Vision Quadra PET/CT device has spatial and time resolution similar to those of the Biograph Vision 600 but exhibits improved sensitivity and NECR because of its extended AFOV. The reported spatial resolution, time resolution, and sensitivity make it a competitive new device in the class of PET scanners with an extended AFOV.