Crystal structure of (±)-(7 RS ,8 SR )-7-methyl-1,4-dioxaspiro[4.5]decane-7,8-diol

In the title compound, C 9 H 16 O 4 , the five-membered dioxolane ring adopts a twist conformation; two adjacent C atoms deviate alternately from the mean plane of other atoms by −0.297 (4) and 0.288 (4) Å. The spiro-fused cyclohexane ring shows a chair form. The hydroxy group substituted in an axia...

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Published inActa crystallographica. Section E, Crystallographic communications Vol. 71; no. 10; pp. 1181 - 1184
Main Authors Oishi, Takeshi, Yamamoto, Hiroaki, Sugai, Tomoya, Fukaya, Keisuke, Yamaguchi, Yu, Watanabe, Ami, Sato, Takaaki, Chida, Noritaka
Format Journal Article
LanguageEnglish
Published International Union of Crystallography 01.10.2015
Subjects
crystal structure
cyclohexane
hydrogen bonds
hydroxy groups
paclitaxel
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Summary:In the title compound, C 9 H 16 O 4 , the five-membered dioxolane ring adopts a twist conformation; two adjacent C atoms deviate alternately from the mean plane of other atoms by −0.297 (4) and 0.288 (4) Å. The spiro-fused cyclohexane ring shows a chair form. The hydroxy group substituted in an axial position makes an intramolecular O—H...O hydrogen bond with one of the O atoms in the cyclic ether, forming an S (6) ring motif. In the crystal, the O—H...O hydrogen bond involving the equatorial hydroxy group connects the molecules into a zigzag chain with a C (5) motif running along the c axis.
ISSN:2056-9890
2056-9890
DOI:10.1107/S2056989015016783