Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of , Moreno-Domínguez show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxid...

Full description

Saved in:
Bibliographic Details
Published inScience signaling Vol. 13; no. 615
Main Authors Bishop, Tammie, Ratcliffe, Peter J
Format Journal Article
LanguageEnglish
Published United States 21.01.2020
Subjects
Carotid Body
Chemoreceptor Cells
Electron Transport Complex IV
Humans
Hypoxia
Oxygen
Protein Isoforms
Online AccessGet more information

Cover

More Information
Summary:The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of , Moreno-Domínguez show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.
ISSN:1937-9145
DOI:10.1126/scisignal.aba1302