Design and manufacture of high-filling-efficiency microfluidic devices
In this study, we proposed an efficient method for mass production of high-filling-efficiency microfluidic devices. Precision machining was the main process of device fabrication. The commercially available SolidWorks software was adopted for structure design. Unigraphics software was then used to s...
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| Published in | International journal of advanced manufacturing technology Vol. 97; no. 5-8; pp. 1711 - 1717 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
London
Springer London
01.07.2018
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
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| Abstract | In this study, we proposed an efficient method for mass production of high-filling-efficiency microfluidic devices. Precision machining was the main process of device fabrication. The commercially available SolidWorks software was adopted for structure design. Unigraphics software was then used to simulate the machining process. The simulated tooling file was then loaded into a CNC milling machine for mold production. The fabricated metal mold was used for pouring polydimethylsiloxane (PDMS) to obtain high-filling-efficiency microfluidic structures. Finally, plasma-assisted packaging was conducted to tightly bind the PDMS microfluidic structure to the glass substrate. Experimental results showed that the additional semicircular filling structure and expended fill-entry structure can efficiently enhance filling efficiency of the microchannel device. The incubation well array can be completely filled at a relatively short filling time. The proposed highly efficient filling microfluidic device possesses advantages, such as feasibility for mass production and cost effectiveness. |
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| AbstractList | In this study, we proposed an efficient method for mass production of high-filling-efficiency microfluidic devices. Precision machining was the main process of device fabrication. The commercially available SolidWorks software was adopted for structure design. Unigraphics software was then used to simulate the machining process. The simulated tooling file was then loaded into a CNC milling machine for mold production. The fabricated metal mold was used for pouring polydimethylsiloxane (PDMS) to obtain high-filling-efficiency microfluidic structures. Finally, plasma-assisted packaging was conducted to tightly bind the PDMS microfluidic structure to the glass substrate. Experimental results showed that the additional semicircular filling structure and expended fill-entry structure can efficiently enhance filling efficiency of the microchannel device. The incubation well array can be completely filled at a relatively short filling time. The proposed highly efficient filling microfluidic device possesses advantages, such as feasibility for mass production and cost effectiveness. |
| Author | Wu, Chun-Te Wang, Gou-Jen |
| Author_xml | – sequence: 1 givenname: Chun-Te surname: Wu fullname: Wu, Chun-Te organization: Department of Mechanical Engineering, National Chung-Hsing University – sequence: 2 givenname: Gou-Jen orcidid: 0000-0002-2405-5474 surname: Wang fullname: Wang, Gou-Jen email: gjwang@dragon.nchu.edu.tw organization: Department of Mechanical Engineering, National Chung-Hsing University, Graduate Institute of Biomedical Engineering, National Chung-Hsing University |
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| CitedBy_id | crossref_primary_10_1016_j_jmatprotec_2021_117394 crossref_primary_10_1007_s00170_021_07020_7 crossref_primary_10_1016_j_chemosphere_2022_137185 crossref_primary_10_1016_j_jmapro_2021_04_057 crossref_primary_10_1016_j_jmapro_2025_01_016 |
| Cites_doi | 10.1007/s10404-013-1291-9 10.1088/0960-1317/13/5/332 10.1007/s00216-006-0327-3 10.1021/ac402383n 10.1038/nprot.2009.234 10.1016/j.aca.2011.12.050 10.1039/C3LC51360B 10.1021/ac100713u 10.1016/S0167-9317(98)00135-X 10.1088/0960-1317/14/3/R01 10.1021/ac9701997 10.1016/j.tibtech.2014.04.010 10.1016/S0925-4005(03)00266-1 10.1039/b507637d 10.1201/9781482274004 |
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| Copyright | Springer-Verlag London Ltd., part of Springer Nature 2018 Copyright Springer Science & Business Media 2018 The International Journal of Advanced Manufacturing Technology is a copyright of Springer, (2018). All Rights Reserved. Springer-Verlag London Ltd., part of Springer Nature 2018. |
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| Keywords | Plasma-assisted packaging Hot embossing High-filling-efficiency microfluidic device Precision machining of molds |
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| SubjectTerms | CAE) and Design Computer-Aided Engineering (CAD Cost effectiveness Efficiency Engineering Glass substrates Industrial and Production Engineering Mass production Mechanical Engineering Media Management Microchannels Microfluidic devices Milling (machining) Milling machines Molds Numerical controls Original Article Polydimethylsiloxane Precision machining Scientific apparatus & instruments Silicone resins Software Tooling |
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