Design and manufacture of high-filling-efficiency microfluidic devices

In this study, we proposed an efficient method for mass production of high-filling-efficiency microfluidic devices. Precision machining was the main process of device fabrication. The commercially available SolidWorks software was adopted for structure design. Unigraphics software was then used to s...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of advanced manufacturing technology Vol. 97; no. 5-8; pp. 1711 - 1717
Main Authors Wu, Chun-Te, Wang, Gou-Jen
Format Journal Article
LanguageEnglish
Published London Springer London 01.07.2018
Springer Nature B.V
Subjects
CAE) and Design
Computer-Aided Engineering (CAD
Cost effectiveness
Efficiency
Engineering
Glass substrates
Industrial and Production Engineering
Mass production
Mechanical Engineering
Media Management
Microchannels
Microfluidic devices
Milling (machining)
Milling machines
Molds
Numerical controls
Original Article
Polydimethylsiloxane
Precision machining
Scientific apparatus & instruments
Silicone resins
Software
Tooling
Plasma-assisted packaging
Hot embossing
High-filling-efficiency microfluidic device
Precision machining of molds
Online AccessGet full text

Cover

More Information
Summary:In this study, we proposed an efficient method for mass production of high-filling-efficiency microfluidic devices. Precision machining was the main process of device fabrication. The commercially available SolidWorks software was adopted for structure design. Unigraphics software was then used to simulate the machining process. The simulated tooling file was then loaded into a CNC milling machine for mold production. The fabricated metal mold was used for pouring polydimethylsiloxane (PDMS) to obtain high-filling-efficiency microfluidic structures. Finally, plasma-assisted packaging was conducted to tightly bind the PDMS microfluidic structure to the glass substrate. Experimental results showed that the additional semicircular filling structure and expended fill-entry structure can efficiently enhance filling efficiency of the microchannel device. The incubation well array can be completely filled at a relatively short filling time. The proposed highly efficient filling microfluidic device possesses advantages, such as feasibility for mass production and cost effectiveness.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0268-3768
1433-3015
DOI:10.1007/s00170-018-2039-1