Biginelli reaction beyond three-component limit: synthesis of functionalized pyrimidinones via a one-pot Biginelli-Pd mediated C–C coupling strategy

A new and one-pot synthesis of novel alkynyl/alkenyl/aryl (hetero)aryl substituted 3,4-dihydropyrimidin-2(1 H)-one derivatives has been developed via a multi-component reaction involving sequential phosphorus acid-mediated solvent-free Biginelli followed by copper-free Sonogashira or Heck or Suzuki...

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Published inTetrahedron letters Vol. 52; no. 11; pp. 1187 - 1191
Main Authors Kumar, P. Mahesh, Kumar, K. Siva, Poreddy, Srinivas Reddy, Mohakhud, Pradeep Kumar, Mukkanti, K., Pal, Manojit
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 16.03.2011
Elsevier
Subjects
Alkene
Alkyne
Aromatic compounds
Boronic acid
Carbon-carbon composites
Catalysis
Chemical reactions
Chemistry
Chemistry, Organic
Coupling
Derivatives
Joining
Physical Sciences
Pyrimidinone
Science & Technology
Strategy
Synthesis (chemistry)
Tetrahedrons
Pyrimidinone
Boronic acid
Alkene
Coupling
Catalysis
Alkyne
BLOCKERS
PALLADIUM
HYDROGEN
ARYL
3,4-DIHYDROPYRIMIDIN-2(1H)-ONES
DIHYDROPYRIMIDINE SYNTHESIS
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Summary:A new and one-pot synthesis of novel alkynyl/alkenyl/aryl (hetero)aryl substituted 3,4-dihydropyrimidin-2(1 H)-one derivatives has been developed via a multi-component reaction involving sequential phosphorus acid-mediated solvent-free Biginelli followed by copper-free Sonogashira or Heck or Suzuki reaction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.01.015