Low Density Lipoprotein Cholesterol and the Outcome of Acute Ischemic Stroke: Results of a Large Hospital-Based Study

Studies show inconsistent associations between low-density lipoprotein cholesterol (LDL-C) and stroke outcome. We assessed these associations among patients with first-ever acute ischemic stroke (AIS) in China. Patients with first-ever AIS were categorized into 3 groups: normal LDL, marginally eleva...

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Bibliographic Details
Published inEuropean neurology Vol. 76; no. 5-6; p. 195
Main Authors Xing, Yonghong, An, Zhongping, Yu, Ning, Zhao, Wenjuan, Ning, Xianjia, Wang, Jinghua
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2016
Subjects
Aged
China
Cholesterol, LDL - blood
Female
Humans
Male
Middle Aged
Prognosis
Recurrence
Risk Factors
Stroke - blood
Stroke - mortality
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Summary:Studies show inconsistent associations between low-density lipoprotein cholesterol (LDL-C) and stroke outcome. We assessed these associations among patients with first-ever acute ischemic stroke (AIS) in China. Patients with first-ever AIS were categorized into 3 groups: normal LDL, marginally elevated LDL and high LDL - according to the LDL-C values on admission. The outcome measures that were investigated in each group included mortality, dependence and recurrence of vascular events. Patients with high LDL-C had higher mortality rates than did those with normal LDL-C at both 12 and 36 months, but this difference disappeared after adjustment for covariates. There was no difference between groups in mortality at 3 months and dependency or recurrence at 3, 12 or 36 months. LDL-C level was associated with long-term mortality after stroke, but was not an independent prognostic factor.
ISSN:1421-9913
DOI:10.1159/000450604