Association of Matrix Metalloproteinase-9 rs3918242 Promoter Genotypes With Colorectal Cancer Risk

• Published in: Anticancer research Vol. 39; no. 12; pp. 6523 - 6529
• Main Authors: WU, MING-HSIEN, TZENG, HUEY-EN, WU, CHENG-NAN, YUEH, TE-CHENG, PENG, YEN-CHUN, TSAI, CHUN-HAO, WANG, YUN-CHI, KE, TAO-WEI, PEI, JEN-SHENG, CHANG, WEN-SHIN, TSAI, CHIA-WEN, BAU, DA-TIAN
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.12.2019
• Subjects: Age; Alcohol use; Body Mass Index; Cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Epidemiology; Extracellular matrix; Female; Gelatinase B; Gender; Gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Genotypes; Health risks; Humans; Male; Matrix metalloproteinase; Matrix Metalloproteinase 9 - genetics; Matrix metalloproteinases; Metalloproteinase; Metastases; Neoplasm Metastasis - genetics; Patients; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Population; Promoter Regions, Genetic; Restriction fragment length polymorphism; Risk; Smoking; Taiwan; Taiwan; China; Case-control study; polymorphism; colorectal cancer; MMP-9; Taiwan; genotype
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.13867

Matrix metalloproteinase-9 (MMP-9) is responsible for modifying extracellular components and plays a crucial role in the metastatic behavior of cancer. This study aimed at examining the role of MMP-9 rs3918242 genotypes on colorectal cancer (CRC) risk. A total of 362 CRC patients and 362 healthy subjects in Taiwan, were examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. The MMP-9 rs3918242 TT genotype carriers had a slightly increased risk of CRC compared to CC carriers (p=0.1642, OR=1.88, 95% CI=0.84-4.16). Patients of CT/TT genotypes were on significantly higher risk of metastasis (p=0.0027) than those of CC genotype. No obvious association was found between MMP-9 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No significant correlation was observed between MMP-9 genotypic distributions with age, gender, tumor size or location. MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.