Rab10 Disruption Results in Delayed OPC Maturation

Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional...

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Published inCellular and molecular neurobiology Vol. 37; no. 7; pp. 1303 - 1310
Main Authors Zhang, Zhao-huan, Zhao, Wei-Qian, Ma, Fan-fei, Zhang, Hui, Xu, Xiao-Hui
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2017
Springer Nature B.V
Subjects
Animals
Animals, Newborn
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
Maturation
Mice
Mice, Knockout
Mice, Transgenic
Myelination
Neurobiology
Neurosciences
Oligodendrocyte Precursor Cells - pathology
Oligodendroglia - physiology
Original Research
rab GTP-Binding Proteins - deficiency
rab GTP-Binding Proteins - genetics
Rats
Rats, Sprague-Dawley
Rodents
siRNA
Membrane addition
MBP
Rab10
OPC
Maturation
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Summary:Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0272-4340
1573-6830
1573-6830
DOI:10.1007/s10571-017-0465-5