Enhanced Antimicrobial Activity of Amine-Phosphonium (N-P) Hybrid Polymers Against Gram-Negative and Gram-Positive Bacteria

The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% s...

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Bibliographic Details
Published inInternational journal of polymeric materials Vol. 64; no. 2; pp. 84 - 89
Main Authors Bansal, Ruby, Pathak, Rajiv, Jha, Diksha, Kumar, Pradeep, Gautam, Hemant K.
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis Group 13.07.2015
Taylor & Francis Ltd
Subjects
Antimicrobial activity
Antimicrobial agents
Bacteria
Biological activity
Biomedical materials
cationic polymers
Chemical synthesis
linear polyethylenimine
phosphonium salts
Polymers
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Summary:The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2014.886246