Increasing effects of S-methyl-l-cysteine on the extracellular d-serine concentrations in the rat medial frontal cortex
In an in vivo dialysis experiment, the intra-medial frontal cortex infusion of a system A and Asc-1 transporter inhibitor, S -methyl- l -cysteine, caused a concentration-dependent increase in the dialysate contents of an endogenous coagonist for the N -methyl- d -aspartate (NMDA) type glutamate rece...
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Published in | Amino acids Vol. 44; no. 5; pp. 1391 - 1395 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Vienna
Springer Vienna
01.05.2013
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | In an in vivo dialysis experiment, the intra-medial frontal cortex infusion of a system A and Asc-1 transporter inhibitor,
S
-methyl-
l
-cysteine, caused a concentration-dependent increase in the dialysate contents of an endogenous coagonist for the
N
-methyl-
d
-aspartate (NMDA) type glutamate receptor,
d
-serine, in the cortical portion. These results suggest that these neutral amino acid transporters could control the extracellular
d
-serine signaling in the brain and be a target for the development of a novel threapy for neuropsychiatric disorders with an NMDA receptor dysfunction. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0939-4451 1438-2199 |
DOI: | 10.1007/s00726-013-1464-6 |