Increasing effects of S-methyl-l-cysteine on the extracellular d-serine concentrations in the rat medial frontal cortex

In an in vivo dialysis experiment, the intra-medial frontal cortex infusion of a system A and Asc-1 transporter inhibitor, S -methyl- l -cysteine, caused a concentration-dependent increase in the dialysate contents of an endogenous coagonist for the N -methyl- d -aspartate (NMDA) type glutamate rece...

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Published inAmino acids Vol. 44; no. 5; pp. 1391 - 1395
Main Authors Ishiwata, Sayuri, Ogata, Shigehiro, Umino, Asami, Shiraku, Hirohisa, Ohashi, Yoshitaka, Kajii, Yasushi, Nishikawa, Toru
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.05.2013
Springer Nature B.V
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Summary:In an in vivo dialysis experiment, the intra-medial frontal cortex infusion of a system A and Asc-1 transporter inhibitor, S -methyl- l -cysteine, caused a concentration-dependent increase in the dialysate contents of an endogenous coagonist for the N -methyl- d -aspartate (NMDA) type glutamate receptor, d -serine, in the cortical portion. These results suggest that these neutral amino acid transporters could control the extracellular d -serine signaling in the brain and be a target for the development of a novel threapy for neuropsychiatric disorders with an NMDA receptor dysfunction.
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ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-013-1464-6