Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study

• Published in: World journal of urology Vol. 37; no. 8; pp. 1649 - 1657
• Main Authors: Cindolo, Luca, Spiess, Philippe E., Bada, Maida, Chipollini, Juan J., Nyirády, Peter, Chiodini, Paolo, Varga, Judith, Ditonno, Pasquale, Battaglia, Michele, De Nunzio, Cosimo, Tema, Giorgia, Veccia, Alessandro, Antonelli, Alessandro, Musi, Gennaro, De Cobelli, Ottavio, Conti, Andrea, Micali, Salvatore, Álvarez-Maestro, Mario, Olarte, José Quesada, Diogenes, Erico, Lima, Marcos Venicio Alves, Tracey, Andrew, Guruli, Georgi, Autorino, Riccardo, Sountoulides, Petros, Schips, Luigi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2019; Springer Nature B.V
• Subjects: Aged; Cancer; Europe; Genital cancers; Guideline Adherence - statistics & numerical data; Humans; Lymph Node Excision; Lymph nodes; Lymphatic Metastasis; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Oncology; Original Article; Patients; Penile Neoplasms - pathology; Penile Neoplasms - surgery; Penis; Retrospective Studies; Societies, Medical; Surgery; Survival; Survival analysis; Urologic Surgical Procedures, Male - standards; Urology; Europe; Lymphadenectomy; Total penile amputation; Partial penectomy; Penile cancer; Survival; Guidelines
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/s00345-018-2549-3

Introduction We aimed to evaluate adherence to the EAU guidelines (GL) on penile cancer (PC) with regard to primary surgical treatment and management of lymph nodes and to estimate the influence of adherence to GL on clinical outcome. Materials and methods This is a retrospective multicenter study (PEnile Cancer ADherence study, PECAD Study) on PC patients treated at 12 European and American centers between 2010 and 2016. Adherence to the EAU GL on the surgical management of the primary penile tumor and lymphadenectomy was evaluated. Descriptive analyses were performed, and survival curves were estimated. Results Data on 425 patients were considered for the analysis. The EAU GL on surgical treatment of the primary tumor and lymphadenectomy were respected in 74.8% and 73.7% of cases, respectively. Survival analysis showed that adherence to the GL on primary penile surgery was significantly associated with a good overall survival [adjusted HR 0.40 (95% CI 0.20–0.83, p value = 0.014)]. Also, the adherence to the GL on lymphadenectomy was statistically significantly associated with overall survival [adjusted HR 0.48 (95% CI 0.24–0.96, p value = 0.038)]. Limited follow-up and retrospective design represent limitations of this study. Conclusions Our findings suggest that there is a good adherence to the EAU GL on PC. However, this should be further reinforced, endorsed and encouraged as it might translate into better clinical outcomes for PC patients.