Chemical characterization and radioprotective effect of polysaccharide from Monostroma angicava (Chlorophyta)

Polysaccharide from the green alga Monostroma angicava was extracted with boiling water and was purified by ion-exchange and size-exclusion column chromatography. The radioprotective effect of the polysaccharide was investigated in mice. The results show that polysaccharide from M. angicava has a di...

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Published inJournal of applied phycology Vol. 17; no. 4; pp. 349 - 354
Main Authors Mao, Wenjun, Li, Yi, Wu, Ligen, Wang, Haiqing, Zhang, Yi, Zang, Xiaoxue, Zhang, Huijuan
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 01.06.2005
Subjects
Biological and medical sciences
Chemical constitution
Chlorophyta
Fundamental and applied biological sciences. Psychology
General pharmacology
Marine
Medical sciences
Monostroma angicava
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant physiology and development
Bioassay
Monostroma angicava
Algae
Rodentia
immune activation
chemical characterization
Radioprotection
Biological activity
Vertebrata
Immunostimulant agent
Mammalia
Chlorophyta
Mouse
radioprotective effect
Chemical composition
Polysaccharide
Thallophyta
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Summary:Polysaccharide from the green alga Monostroma angicava was extracted with boiling water and was purified by ion-exchange and size-exclusion column chromatography. The radioprotective effect of the polysaccharide was investigated in mice. The results show that polysaccharide from M. angicava has a different chemical composition to other Chlorophyta having a high rhamnose - containing sulfated polysaccharide. The sulfate ester content was estimated to be 21.8%. When the polysaccharide was applied to BALB/c mice following whole-body X-ray irradiation the counts of leukocytes, thrombocytes and erythrocytes recovered more rapidly in the polysaccharide treated mice after irradiation. In the irradiated mice, the polysaccharide significantly increased the spleen index, natural killer cytostatic activity and the transformation response of splenic lymphocytes. The present observations suggest that polysaccharide from M. angicava led to leukocytogensis and hematopoetic activation in mice after irradiation and that the biological response might be caused by immune activation.
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ISSN:0921-8971
1573-5176
DOI:10.1007/s10811-005-8360-8