Tissue-engineered Vascular Grafts: Balance of the Four Major Requirements

Tissue-engineered vascular grafts (TEVGs) have emerged as a new choice for substitution of damaged blood vessels. A passage of a new blood vessel can be regenerated through the continuous secretion of extracellular matrix of cells seeded on the TEVGs, which is not possible using conventional vascula...

Full description

Saved in:
Bibliographic Details
Published inColloid and interface science communications Vol. 23; pp. 34 - 44
Main Authors Wu, Jingxian, Hu, Changming, Tang, Zengchao, Yu, Qian, Liu, Xiaoli, Chen, Hong
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2018
Subjects
Biodegradability
Blood compatibility
Endothelium friendliness
Matched mechanical properties
Tissue engineering
Vascular grafts
Endothelium friendliness
Blood compatibility
Matched mechanical properties
Tissue engineering
Biodegradability
Vascular grafts
Online AccessGet full text

Cover

More Information
Summary:Tissue-engineered vascular grafts (TEVGs) have emerged as a new choice for substitution of damaged blood vessels. A passage of a new blood vessel can be regenerated through the continuous secretion of extracellular matrix of cells seeded on the TEVGs, which is not possible using conventional vascular grafts. Although great progress has been made in TEVGs technology with advances in scaffold design and cell seeding, none have been applied in clinic hitherto. This review summarized the progress of TEVGs during the recent 7 years on the basis of four major requirements of TEVGs, namely, matched mechanical properties, blood compatibility, endothelium friendliness and biodegradability, in the hope of promoting the development of TEVGs. [Display omitted] •Techniques for fabricating tissue-engineered vascular grafts are summarized.•The four major requirements of TEVG are reviewed.•Some perspectives regarding future research of TEVG are presented.
ISSN:2215-0382
2215-0382
DOI:10.1016/j.colcom.2018.01.005