Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome

• Published in: Journal of endocrinological investigation Vol. 39; no. 11; pp. 1269 - 1275
• Main Authors: Karakose, M., Demircan, K., Tutal, E., Demirci, T., Arslan, M. S., Sahin, M., Celik, H. T., Kazanci, F., Karakaya, J., Cakal, E., Delibasi, T.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2016; Springer Nature B.V
• Subjects: ADAMTS1 Protein - blood; ADAMTS5 Protein - blood; ADAMTS9 Protein - blood; Adult; Biomarkers - blood; Case-Control Studies; Clinical significance; Cytokines; Cytokines - blood; Endocrinology; Enzyme-Linked Immunosorbent Assay; Female; Fertility; Humans; Immunology; Inflammation; Interleukin-17 - blood; Interleukin-23 - blood; Interleukin-33 - blood; Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - diagnosis; Young Adult; Polycystic ovary syndrome; ADAMTS; Insulin resistance; Interleukin
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-016-0472-2

Purpose Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) are involved in inflammation and fertility. The aim of this investigation was to evaluate the serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL-17, IL-23, IL-33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS patients. Methods A case-control study was performed in a training and research hospital. Eighty patients with PCOS and seventy-eight healthy female volunteers were recruited in the present study. Serum ADAMTS and IL levels were determined by a human enzyme-linked immunoassay (ELISA) in all subjects. Results The IL-17A, IL-23 and IL-33 levels were significantly higher in the PCOS patients compared to the controls ( p  < 0.05). We could not find significant difference between the groups in terms of ADAMTS1, ADAMTS5 and ADAMTS9 levels. IL-17A had positive correlations with LDL cholesterol and IL-33 and negative correlations with ADAMTS1, ADAMTS5, and ADAMTS9. IL-33 had positive correlation with LDL cholesterol and IL-17A. In ROC curve analysis, PCOS can be predicted by the use of IL-17A, IL-23 and IL-33 which at a cut-off value of 8.37 pg/mL (44 % sensitivity, 83 % specificity), 26.75 pg/mL (36 % sensitivity, 64 % specificity) and 14.28 pg/mL (83 % sensitivity, 39 % specificity), respectively. Conclusions The results of the study might suggest that ADAMTS and IL molecules have a role in the pathogenesis of the PCOS. Further efforts are needed to establish causality for ADAMTS-IL axis.