Functional Neuroimaging in PTSD: From Discovery of Underlying Mechanisms to Addressing Diagnostic Heterogeneity

Despite extensive research, available psychotherapics and pharmacotherapies for posttraumatic stress disorder (PTSD) have shown only limited benefits. The cause of limited treatment efficacy in PTSD may lie not only in the treatments themselves but in the heterogeneity within the diagnosis of PTSD....

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 178; no. 2; pp. 128 - 135
Main Author Neria, Yuval
Format Journal Article
LanguageEnglish
Published United States American Psychiatric Association 01.02.2021
Subjects
Animals
Big Data
Brain Mapping
Fear
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Medical diagnosis
Medical treatment
Neuroimaging
Post traumatic stress disorder
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - psychology
Neuroimaging
fMRI
Conditioning
Comorbidity
Resting-State Functional Connectivity
Posttraumatic Stress Disorder (PTSD)
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Summary:Despite extensive research, available psychotherapics and pharmacotherapies for posttraumatic stress disorder (PTSD) have shown only limited benefits. The cause of limited treatment efficacy in PTSD may lie not only in the treatments themselves but in the heterogeneity within the diagnosis of PTSD. PTSD is currently defined by exposure to a wide variety of traumatic events and by a broad constellation of physical, affective, behavioral, and cognitive symptoms. Improving the diagnostic specificity of PTSD would yield more homogeneous patient samples and increase the likelihood of identifying clinically meaningful neurobiological markers, which could in turn serve as objective. measurable targets for novel and specific treatments. In trying to address the problem, functional neuroimaging studies have become central to efforts to characterize neural markers of PTSD.
Bibliography:ObjectType-Article-2
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ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.2020.20121727