Studies towards the total synthesis of Sch 56036; isoquinolinone synthesis and the synthesis of phenanthrenes

• Published in: Tetrahedron letters Vol. 46; no. 38; pp. 6537 - 6540
• Main Authors: Walker, Edward R., Leung, Shing Y., Barrett, Anthony G.M.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 19.09.2005; Elsevier
• Subjects: Albofungin; Antifungal natural product; Chemistry; Chemistry, Organic; Palladium coupling; Phenanthrene; Physical Sciences; Pomeranz–Fritsch reaction; Ring closing metathesis; Sch 56036; Science & Technology; Sch 56036; Pomeranz–Fritsch reaction; Ring closing metathesis; Phenanthrene; Antifungal natural product; Palladium coupling; Albofungin; ANALOG; antifungal natural product; ACIDS; albofungin; Pomeranz-Fritsch reaction; CYCLIC ETHERS; ring closing metathesis; ORTHO-ALLYLPHENOLS; (+/-)-CERVINOMYCIN-A2; phenanthrene
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2005.07.084

The isoquinolinone hemisphere of Sch 56036 has been prepared using a modified Pomeranz–Fritsch reaction and the synthesis of the phenanthrene core has been modelled via a Suzuki coupling and subsequent ring closing metathesis. The isoquinolinone hemisphere of Sch 56036 has been prepared using a modified Pomeranz–Fritsch reaction and the synthesis of the phenanthrene core has been modelled via a Suzuki coupling and subsequent ring closing metathesis.