Molecular profiles in foregut oncology

Oncology is and will continue to evolve resulting from a better understanding of the biology and intrinsic genetic profile of each cancer. Tumor biomarkers and targeted therapies are the new face of precision medicine, so it is essential for all physicians caring for cancer patients to understand an...

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Published inCancer genetics Vol. 209; no. 12; pp. 537 - 553
Main Authors Sukharamwala, Prashant, Hennessey, Daniel, Wood, Thomas, Singh, Shelly, Ryan, Carrie, Rosemurgy, Alexander
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2016
Subjects
Biomarkers, Tumor - genetics
Cancer
digestive system
Gastrointestinal Neoplasms - drug therapy
Gastrointestinal Neoplasms - genetics
Hematology, Oncology and Palliative Medicine
Humans
liver
Medical Education
Molecular Targeted Therapy
neoplasm
Precision Medicine
Transcriptome
tumor marker
digestive system
neoplasm
tumor marker
liver
Cancer
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Summary:Oncology is and will continue to evolve resulting from a better understanding of the biology and intrinsic genetic profile of each cancer. Tumor biomarkers and targeted therapies are the new face of precision medicine, so it is essential for all physicians caring for cancer patients to understand and assist patients in understanding the role and importance of such markers and strategies to target them. This review was initiated in an attempt to identify, characterize, and discuss literature supporting clinically relevant molecular markers and interventions. The efficacy of targeting specific markers will be examined with data from clinical trials focusing on treatments for esophageal, gastric, liver, gallbladder, biliary tract, and pancreatic cancers.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2210-7762
2210-7770
DOI:10.1016/j.cancergen.2016.09.008