Novel biogenic preparation of gold nanoparticles decorated on sepiolite clay and evaluation of anti-cancer effect on gastric cancer cell and electrochemical sensing of nitrite

• Published in: Environmental research Vol. 238; no. Pt 2; p. 117260
• Main Authors: Huang, Yakai, Zhang, Yingjing, Zhang, Yu, Liu, Wenping, Fang, Yantian, Motlagh, Masoud
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2023
• Subjects: adenocarcinoma; antineoplastic activity; Biogenic preparation; biosynthesis; carbon; cell lines; clay; cytotoxicity; detection limit; electrochemistry; electrodes; Gold nanoparticles; grasses; Heracleum persicum; Heracleum persicum extract; Human gastric adenocarcinoma; humans; nanogold; neoplasm cells; Nitrite; nitrites; oxidation; sepiolite; Sepiolite clay; stomach neoplasms; toxicity testing; transmission electron microscopy; X-ray diffraction; Sepiolite clay; Biogenic preparation; Nitrite; Human gastric adenocarcinoma; Gold nanoparticles; Heracleum persicum extract
• ISSN: 0013-9351; 1096-0953; 1096-0953
• DOI: 10.1016/j.envres.2023.117260

An environmentally friendly strategy was used in this study to synthesize gold nanoparticles decorated on sepiolite clay (GNPs-SC) using Heracleum persicum grass extract. The physicochemical characters of the prepared composite were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray diffraction (XRD). A GNPs-SC modified carbon pate electrode (CPE) was used to study the electrochemical oxidation of nitrite. The proposed nitrite sensor exhibits excellent performance, including a broad linear range (1.0–150 μM), a low limit of detection (0.4 μM), and acceptable reproducibility (RSD = 2.6%). As well, the prepared GNPs-SC was tested for its effectiveness against human gastric adenocarcinoma (AGS) cell line. The MTT assay protocol revealed that the bio-synthesized product displayed significant cytotoxic activity against gastric cancer in human subjects. The findings of this study indicate that GNPs-SC, synthesized using environmentally friendly protocol, exhibit great potential for use in electrochemical sensing and treatment of human cancer. [Display omitted] •Gold nanoparticles decorated on sepiolite clay were prepared using non-toxic green strategy.•A remarkable anticancer property was observed against the human gastric adenocarcinoma (AGS) cell line.•The fabrication of an effective electrochemical sensor for nitrite detection was achieved using the GNPs-SC.