The Recovery of Beta-Cell Function is Critical for Antidiabetic Outcomes of Gastric Bypass in Asian Subjects with Type 2 Diabetes and a Body Mass Index Below 30

• Published in: Obesity surgery Vol. 27; no. 2; pp. 541 - 544
• Main Authors: Kwon, Obin, Lee, Yeon Ji, Yu, Ji Hee, Kim, Min-Seon, Heo, Yoonseok
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2017; Springer Nature B.V
• Subjects: Asian Continental Ancestry Group; Asian people; Body Mass Index; Brief Communication; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - surgery; Gastric Bypass - statistics & numerical data; Gastrointestinal surgery; Humans; Insulin; Insulin-Secreting Cells - physiology; Medicine; Medicine & Public Health; Pilot Projects; Surgery; Surgical outcomes; Type 2 diabetes; Body mass index; Beta-cell; Asian; Gastric bypass
• ISSN: 0960-8923; 1708-0428; 1708-0428
• DOI: 10.1007/s11695-016-2455-y

Type 2 diabetes (T2D) in Asian populations is characterized by a lower body mass index (BMI) than in Caucasian cases. This pilot study investigated antidiabetic outcomes after a Roux-en-Y gastric bypass (RYGB) in Asian subjects with T2D and BMI < 30. Fifteen Koreans with poorly controlled T2D and BMI 23–30 underwent RYGB. Two years after RYGB, seven patients achieved HbA 1c  < 6.5% without medication (target-achieved). The other cases also showed improved glycemic control. The insulin secretory response during an oral glucose tolerance test was significantly restored in the target-achieved group. Postoperative changes in insulin sensitivity and body weight did not differ between these groups. Beta-cell function improvement is an important determinant of the long-term antidiabetic outcomes of RYGB in Asian subjects with BMI < 30.