Gut Microbiota and Immunotherapy

The gut microbiota is the largest microbiota in the body, which is closely related to the immune state of the body. A number of studies have shown that gut microbiota and its metabolites are involved in host immune regulation. Immune checkpoint inhibitors have become an important drug for the treatm...

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Bibliographic Details
Published inFrontiers in microbiology Vol. 13; p. 945887
Main Authors Xu, Xiaoqing, Ying, Jieer
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 01.07.2022
Subjects
immunotherapy
immunotherapy response
interaction
Microbiology
microbiome manipulation
the gut microbiota
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Summary:The gut microbiota is the largest microbiota in the body, which is closely related to the immune state of the body. A number of studies have shown that gut microbiota and its metabolites are involved in host immune regulation. Immune checkpoint inhibitors have become an important drug for the treatment of many malignant tumors, which can significantly improve the prognosis of tumor patients. However, a considerable number of patients cannot benefit from immune checkpoint inhibitors. At present, the known treatment methods of microbiota manipulation mainly include fecal microbiota transplantation, dietary regulation, prebiotics and so on. Therefore, this paper will discuss the possibility of improving the anti-tumor efficacy of immunotherapy from the perspectives of the gut microbiota and immunotherapy.
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Edited by: Guillermo Tellez-Isaias, University of Arkansas, United States
This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology
Reviewed by: Santiago Uribe-Diaz, University of Arkansas, United States; Jesús Adonai Maguey González, National Autonomous University of Mexico, Mexico
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.945887