Synthesis of quinaldines and lepidines by a Doebner–Miller reaction under thermal and microwave irradiation conditions using phosphotungstic acid

A simple and efficient method has been developed for the synthesis of quinaldines and lepidines by a one-pot reaction of anilines with crotonaldehyde or methyl vinyl ketone using phosphotungstic acid, a Keggins-type heteropoly acid, under both thermal and microwave irradiation conditions. A simple a...

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Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 11; pp. 1783 - 1785
Main Authors Sivaprasad, Ganesabaskaran, Rajesh, Rengasamy, Perumal, Paramasivan T.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 13.03.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
QUINOLINES
HETEROPOLY ACIDS
CYCLOTRIMERIZATION
DERIVATIVES
CATALYZED SYNTHESIS
ANILINES
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Summary:A simple and efficient method has been developed for the synthesis of quinaldines and lepidines by a one-pot reaction of anilines with crotonaldehyde or methyl vinyl ketone using phosphotungstic acid, a Keggins-type heteropoly acid, under both thermal and microwave irradiation conditions. A simple and efficient method has been developed for the synthesis of quinaldines and lepidines by a one-pot reaction of anilines with crotonaldehyde or methyl vinyl ketone using phosphotungstic acid, a Keggins-type heteropoly acid, under both thermal and microwave irradiation conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.01.034