The relationship of 19 functional polymorphisms in iodothyronine deiodinase and psychological well-being in hypothyroid patients

• Published in: Endocrine Vol. 57; no. 1; pp. 115 - 124
• Main Authors: Young Cho, Yoon, Jeong Kim, Hye, Won Jang, Hye, Hyuk Kim, Tae, Ki, Chang-Seok, Wook Kim, Sun, Hoon Chung, Jae
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2017; Springer Nature B.V
• Subjects: Adult; Alleles; Desorption; Diabetes; Endocrinology; Female; Gene Frequency; Genotype; Genotyping; Homeostasis; Humanities and Social Sciences; Humans; Hypothyroidism; Hypothyroidism - genetics; Hypothyroidism - psychology; Internal Medicine; Iodide peroxidase; Iodide Peroxidase - genetics; Ions; Lasers; Male; Mass spectroscopy; Medicine; Medicine & Public Health; Mental Health; Middle Aged; multidisciplinary; Original Article; Personal Satisfaction; Polymorphism, Single Nucleotide; Prospective Studies; Science; Single-nucleotide polymorphism; Supplements; Surveys and Questionnaires; Thyroid cancer; Thyroid gland; Thyroiditis; Thyroxine; Thyroxine deiodinase; Iodothyronine deiodinase; Hypothyroidism; Psychological well-being; Polymorphism
• ISSN: 1355-008X; 1559-0100
• DOI: 10.1007/s12020-017-1307-4

Purpose Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relationship between commonly inherited variations in type 2 iodothyronine deiodinase and impaired well-being. We evaluated the prevalence of iodothyronine deiodinase genotypes and their association with psychological well-being in the Korean hypothyroid population. Methods A prospective observational study. We enrolled 196 hypothyroid subjects (136 chronic autoimmune thyroiditis and 60 thyroid cancer) and assessed baseline well-being using six validated questionnaires. Genotyping was conducted for 19 single nucleotide polymorphisms in type 1, 2, and 3 iodothyronine deiodinase using Sequenom MassARRAY matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in all patients. Results Frequencies of iodothyronine deiodinase genotypes and well-being scores were not different in hypothyroid subjects according to their disease types. Minor genotypes of a few iodothyronine deiodinase 1 variants (rs11206244, rs2294512, and rs4926616) were associated with reduced psychological well-being. However, iodothyronine deiodinase 2 and 3 variants had no effect on baseline well-being. Conclusion Minor variations in iodothyronine deiodinase 1 were associated with decreased well-being in the Korean hypothyroid population, whereas iodothyronine deiodinase 2 and 3 were not. Due to controversial results among different ethnicities, further studies to clarify the effects of iodothyronine deiodinase polymorphisms on psychological well-being are warranted in hypothyroid individuals.