Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain
Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive (TH + ) neurons in the posterior tuberculum area. It suggests that Nr4a2 expressio...
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Published in | Journal of molecular neuroscience Vol. 51; no. 3; pp. 719 - 723 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.11.2013
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Our previous study showed that although
Nr4a2b
transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of
Nr4a2
caused a decrease in the number of TH-positive (TH
+
) neurons in the posterior tuberculum area. It suggests that
Nr4a2
expression in the progenitors may play an important role in regulating differentiation rather than survival of TH
+
progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and
Nr4a2
in adult zebrafish brain and found that
Nr4a2b
was co-localized with the spindle-shaped TH
+
cells in the posterior tuberculum area and some small round TH
+
cells in the pretectum area, but not with large pear-shaped TH
+
cells in adult zebrafish diencephalon. In the pretectum area,
Nr4a
2
+
cells were localized next to the dorsal side of TH
+
cells. Furthermore, we demonstrated that
Nr4a2
was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of
Nr4a2
and nestin in these areas was remarkably declined with aging. These findings indicate that
Nr4a2
is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in
Nr4a2
expression with aging suggests its possible association with neurodegenerative diseases. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0895-8696 1559-1166 |
DOI: | 10.1007/s12031-013-0054-0 |