Preparation of tetra-Boc-protected polymyxin B nonapeptide

A method for the selective tetra-Boc-protection of polymyxin B nonapeptide (PMBN) has been developed. A method for the selective tetra-Boc-protection of polymyxin B nonapeptide (PMBN) has been developed. Boc-ON selectively protects the amino side chains of the four diaminobutyric acid (Dab) residues...

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Bibliographic Details
Published inTetrahedron letters Vol. 48; no. 11; pp. 2003 - 2005
Main Authors O’Dowd, Hardwin, Kim, Bum, Margolis, Peter, Wang, Wen, Wu, Charlotte, Lopez, Sara L., Blais, Johanne
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 12.03.2007
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ANTIBIOTICS
INFECTIONS
GRAM-NEGATIVE BACTERIA
MULTIRESISTANT
COLISTIN NONAPEPTIDE
DERIVATIVES
CHEMICAL SYNTHESIS
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Summary:A method for the selective tetra-Boc-protection of polymyxin B nonapeptide (PMBN) has been developed. A method for the selective tetra-Boc-protection of polymyxin B nonapeptide (PMBN) has been developed. Boc-ON selectively protects the amino side chains of the four diaminobutyric acid (Dab) residues in the presence of the N-terminal free amine.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.01.071