Dietary Lactobacillus plantarum alleviated Salmonella Typhimurium infection and suppressed Jak/Stat pathway in rabbits

• Published in: Veterinární medicína Vol. 67; no. 10; pp. 519 - 526
• Main Authors: Wen, Fengyun, Liu, Xiaoping, Ding, Ke, Zhang, Feike, Wang, Jianping
• Format: Journal Article
• Language: English
• Published: Czech Republic Czech Academy of Agricultural Sciences (CAAS) 01.07.2022; Czech Academy of Agricultural Sciences
• Subjects: Body weight; Body weight gain; Colonization; Diet; Feed efficiency; growth performance; IL-1β; Infections; Inflammation; inflammatory cytokines; Interleukin 6; Janus kinase; Janus kinase 2; Kinases; Lactobacilli; Lactobacillus plantarum; Original Paper; Probiotics; Rabbits; Salmonella; Salmonella Typhimurium; Translocation; Tumor necrosis factor-α; growth performance; inflammatory cytokines
• ISSN: 0375-8427; 1805-9392
• DOI: 10.17221/34/2021-VETMED

This study aimed to investigate the effect of a  DPP8 supplementation on the growth performance, pathogenic invasion, inflammation and pathogen resistance signal pathway in rabbits infected with Typhimurium (  Typhimurium). The treatments included a negative control, a positive control with an   Typhimurium infection and a positive control plus DPP8 at 10 , 10 or 10  cfu/kg of diet using 300 weaned rabbits. The results showed that supplementing with DPP8 improved (  < 0.05) the feed intake, body weight gain and feed efficiency compared to the positive control. Also, DPP8 decreased (  < 0.05) the  Typhimurium colonisation and translocation, serum IL-1β, IL-6 and TNF-α, and intestinal mucosa mRNA expressions of the inflammatory mediators Janus kinase (Jak) 2, the signal transducer and activator of transcription (Stat) 1 and 3 at 7 and 14 d post administration. The dose analysis of DPP8 showed linear increases (  ≤ 0.007) in the feed intake and body weight gain, but linear decreases (  ≤ 0.022) in the  Typhimurium loads, IL-1β, IL-6 and Jak2. It is concluded that DPP8 can be used as a supportive probiotic against an   Typhimurium infection and it possibly plays a direct or indirect role in the downregulation of the Jak/Stat pathway in rabbits.