Dietary Lactobacillus plantarum alleviated Salmonella Typhimurium infection and suppressed Jak/Stat pathway in rabbits
This study aimed to investigate the effect of a DPP8 supplementation on the growth performance, pathogenic invasion, inflammation and pathogen resistance signal pathway in rabbits infected with Typhimurium ( Typhimurium). The treatments included a negative control, a positive control with an Typ...
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Published in | Veterinární medicína Vol. 67; no. 10; pp. 519 - 526 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Czech Republic
Czech Academy of Agricultural Sciences (CAAS)
01.07.2022
Czech Academy of Agricultural Sciences |
Subjects | |
Online Access | Get full text |
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Summary: | This study aimed to investigate the effect of a
DPP8 supplementation on the growth performance, pathogenic invasion, inflammation and pathogen resistance signal pathway in rabbits infected with
Typhimurium (
Typhimurium). The treatments included a negative control, a positive control with an
Typhimurium infection and a positive control plus DPP8 at 10
, 10
or 10
cfu/kg of diet using 300 weaned rabbits. The results showed that supplementing with DPP8 improved (
< 0.05) the feed intake, body weight gain and feed efficiency compared to the positive control. Also, DPP8 decreased (
< 0.05) the
Typhimurium colonisation and translocation, serum IL-1β, IL-6 and TNF-α, and intestinal mucosa mRNA expressions of the inflammatory mediators Janus kinase (Jak) 2, the signal transducer and activator of transcription (Stat) 1 and 3 at 7 and 14 d post administration. The dose analysis of DPP8 showed linear increases (
≤ 0.007) in the feed intake and body weight gain, but linear decreases (
≤ 0.022) in the
Typhimurium loads, IL-1β, IL-6 and Jak2. It is concluded that
DPP8 can be used as a supportive probiotic against an
Typhimurium infection and it possibly plays a direct or indirect role in the downregulation of the Jak/Stat pathway in rabbits. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0375-8427 1805-9392 |
DOI: | 10.17221/34/2021-VETMED |