Tissue-targeted metabonomics: biological considerations and application to doxorubicin-induced hepatic oxidative stress

• Published in: Metabolomics Vol. 5; no. 2; pp. 219 - 228
• Main Authors: Price, Kristin E, Larive, Cynthia K, Lunte, Craig E
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.06.2009; Springer US; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Developmental Biology; Life Sciences; Molecular Medicine; Original Article; Oxidative stress; Rodents; Oxidative stress; Anesthesia; NMR; Microdialysis; Doxorubicin; Metabonomics

Tissue-targeted metabonomics, or the use of microdialysis sampling with NMR detection, can be used to monitor the metabolic profiles of specific tissues without the need to take tissue biopsies. This allows for sampling from the same animal over the time course of the experiment, reducing animal-to-...