Poly (vinyl chloride) matrix membrane sensors for the quantification of olopatadine and oxeladine in pharmaceutical preparations and human plasma

• Published in: Microchemical journal Vol. 147; pp. 170 - 175
• Main Authors: Sebaiy, Mahmoud M., Elmosallamy, Mohamed A.F., Elhenawee, Magda M., Alshuwaili, Mustafa Kh
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2019
• Subjects: Human plasma; Olopatadine hydrochloride; Oxeladine citrate; Pharmaceutical preparations; Sensors; Olopatadine hydrochloride; Pharmaceutical preparations; Human plasma; Sensors; Oxeladine citrate
• ISSN: 0026-265X; 1095-9149
• DOI: 10.1016/j.microc.2019.03.030

Two novel potentiometric sensors were developed for the quantification of olopatadine hydrochloride and oxeladine citrate in pure forms, pharmaceutical preparations and human plasma. The both sensors were fabricated on incorporating the olopatadine and oxeladine tetraphenylborate ion-pairs as electroactive materials in plasticized poly (vinyl chloride) matrix membranes with o-nitrophenyl octyl ether. They displayed Nernstian and near Nernstian responses over the concentration ranges of 1.0 × 10−5–1.0 × 10−2 mol L−1 oxeladine and olopatadine with cationic slopes of 60 and 50 mV decade−1, respectively. Detection limits were reported to be 4.4 × 10−6 and 5.0 × 10−6 mol L−1 while the response times were 3.0 and 18 s for oxeladine and olopatadine, respectively. The useful ranges of pH were 2.5–8.5 and 3.0–4.5 for oxeladine and olopatadine, respectively. The life extents were long (3 months) for both sensors. The sensors were successfully used for the assay of oxeladine and olopatadine in pharmaceutical dosage forms with a recovery of 100.0% for both drugs. Also the oxeladine sensor was used for the estimation of the drug in human plasma with an average recovery of 99.49%. •This work involves a development of novel sensors for olopatadine and oxeladine drugs based on using drug-tetraphenyl borate ion-pairs as electroactive materials.•The sensors are used for the determination of the drugs in pure forms, pharmaceutical preparations, and human plasma.•There is no potentiometric sensor reported for the estimation of olopatadine, so far.•These methods are simple, direct, accurate, sensitive and cost affordable for the estimation of the drugs, and also validated for use either in drug quality-control or pharmacokinetic studies according to the quality-assurance standards.