Copper-catalyzed synthesis of aromatic carboxylic acids from arylboronic acids and acetyl acetate

A simple and efficient copper-catalyzed method for the synthesis of aromatic carboxylic acids in moderate to high yields with great functional-group compatibility in the substrates has been developed. The new method uses readily available arylboronic acids and acetyl acetate as the starting material...

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Bibliographic Details
Published inTetrahedron letters Vol. 55; no. 41; pp. 5671 - 5675
Main Authors Zheng, Rui, Zhou, Qizhong, Gu, Haining, Jiang, Huajiang, Wu, Jiashou, Jin, Zhengneng, Han, Deman, Dai, Guoliang, Chen, Rener
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 08.10.2014
Elsevier
Subjects
Acetyl acetate
Aromatic carboxylic acids
Arylboronic acids
Chemistry
Chemistry, Organic
Copper
Physical Sciences
Science & Technology
Aromatic carboxylic acids
Acetyl acetate
Copper
Arylboronic acids
BOND-CLEAVAGE
BORONIC ACIDS
CROSS-COUPLING REACTIONS
ARYL HALIDES
ESTERS
C-C
OXIDATIVE CLEAVAGE
EFFICIENT
DERIVATIVES
WATER
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Summary:A simple and efficient copper-catalyzed method for the synthesis of aromatic carboxylic acids in moderate to high yields with great functional-group compatibility in the substrates has been developed. The new method uses readily available arylboronic acids and acetyl acetate as the starting materials and inexpensive CuI as the catalyst.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.08.090