The Dendritic Cell Dilemma in the Skin: Between Tolerance and Immunity

Dendritic cells (DC) are uniquely capable of initiating and directing immune responses. The range of their activities grounds in the heterogeneity of DC subsets and their functional plasticity. Numerical and functional DC changes influence the development and progression of disease, and correction o...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 13; p. 929000
Main Authors Scheib, Nils, Tiemann, Jessica, Becker, Christian, Probst, Hans Christian, Raker, Verena Katharina, Steinbrink, Kerstin
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 28.06.2022
Subjects
cellular immunotherapy
DC targeted vaccines
dendritic cells
Immunology
interleukin 10
tolerance
treg cells
Online AccessGet full text

Cover

More Information
Summary:Dendritic cells (DC) are uniquely capable of initiating and directing immune responses. The range of their activities grounds in the heterogeneity of DC subsets and their functional plasticity. Numerical and functional DC changes influence the development and progression of disease, and correction of such dysregulations has the potential to treat disease causally. In this review, we discuss the major advances in our understanding of the regulation of DC lineage formation, differentiation, and function in the skin. We describe the alteration of DC in disease as well as possibilities for therapeutic reprogramming with a focus on tolerogenic DC. Because regulatory T cells (Treg) are indispensable partners of DC in the induction and control of tolerance, we pay special attention to the interactions with these cells. Above all, we would like to arouse fascination for this cell type and its therapeutic potential in skin diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Helmut Jonuleit, Johannes Gutenberg University Mainz, Germany
This article was submitted to Vaccines and Molecular Therapeutics, a section of the journal Frontiers in Immunology
Reviewed by: Manfred B. Lutz, Julius Maximilian University of Würzburg, Germany; Markus Philipp Radsak, Johannes Gutenberg University Mainz, Germany
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.929000