Adiponectin as a potential marker of prostate cancer progression: studies in organ-confined and locally advanced prostate cancer

Serum levels of adiponectin were measured in patients with benign prostatic hyperplasia and prostate cancer of pT2 and pT3 stage. Adiponectin ELISA assay, immunohistochemistry, and selected metabolic and biochemical parameters measurement was performed in 25 patients with benign prostatic hyperplasi...

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Published inPhysiological research Vol. 57; no. 3; pp. 451 - 458
Main Authors Housa, D, Vernerová, Z, Heráček, J, Procházka, B, Čechák, P, Kuncová, J, Haluzík, M
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 01.01.2008
Subjects
Adiponectin - blood
Aged
Apoptosis
Biomarkers, Tumor - blood
Disease
Enzyme-Linked Immunosorbent Assay
Humans
Immunohistochemistry
Kinases
Male
Mens health
Middle Aged
Mortality
Neoplasm Invasiveness
Neoplasm Staging
Obesity
Physical examinations
Prostate cancer
Prostatectomy
Prostatic Hyperplasia - metabolism
Prostatic Hyperplasia - pathology
Prostatic Hyperplasia - surgery
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Radiation therapy
Risk factors
Studies
Vitamin D
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Summary:Serum levels of adiponectin were measured in patients with benign prostatic hyperplasia and prostate cancer of pT2 and pT3 stage. Adiponectin ELISA assay, immunohistochemistry, and selected metabolic and biochemical parameters measurement was performed in 25 patients with benign prostatic hyperplasia and 43 with prostate cancer (17 patients with organ-confined and 26 patients with locally advanced disease). Serum adiponectin levels did not differ between prostate benign hyperplasia and cancer clinical stage T2, but was significantly higher in pT3 relative to pT2 group (14.51+/-4.92 vs. 21.41+/-8.12, P = 0.003). Tissue immunohistochemistry showed enhanced staining in neoplastic prostate glands and intraepithelial neoplasia relative to benign prostatic hyperplasia without distinction between disease grade and stage. Serum adiponectin levels are higher in locally advanced relative to organ-confined prostate cancer and may thus serve as an auxiliary marker providing further improvement for discrimination between pT2 and pT3 stages.
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ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.931156