Neurologic manifestations of elderly patients with cancer

• Published in: Aging clinical and experimental research Vol. 31; no. 2; pp. 201 - 207
• Main Authors: Cacho-Díaz, Bernardo, Lorenzana-Mendoza, Nydia A., Reyes-Soto, Gervith, Ávila-Funes, José A., Navarrete-Reyes, Ana P.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2019; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Breast cancer; Cancer; Cross-Sectional Studies; Dementia - etiology; Female; Geriatrics/Gerontology; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasms - complications; Neoplasms - psychology; Nervous System Diseases - etiology; Quality of Life; Stroke - etiology; Tumors; Vertigo - etiology; Neuro-oncology; Elderly; Neoplasms; Cancer; Quality of life
• ISSN: 1720-8319; 1594-0667; 1720-8319
• DOI: 10.1007/s40520-018-0961-6

Background The incidence of cancer is an age-related phenomenon; therefore, the interest on clinical manifestations, diagnostic approach and treatment strategies for older patients diagnosed with cancer has increased lately. Neurologic symptoms are one of the main reasons for consultation and a common cause of decreased quality of life among cancer patients. Aims To identify the neurologic manifestations of patients ≥ 65 years of age diagnosed with cancer and compare them to those presented by a younger population. Methods Cross-sectional study of cancer patients referred to neuro-oncologic consultation at a Cancer Center. Sociodemographic, health and oncologic characteristics were obtained through clinical interviews. Clinical symptoms and final diagnoses were also recorded. Bivariate logistic regression analyses were carried out. Results More than 17,000 neuro-oncologic consultations in 3015 patients were given, 27% ( n  = 811) of them were ≥ 65 years of age. Most frequent primary neoplasms in elderly patients were: breast cancer, hematologic neoplasms, gynecological, urologic, skin and head and neck cancers. Elderly patients had an increased risk of having the following diagnoses: abnormal movements, stroke, peripheral vertigo, dementia, degenerative spine disorder, and delirium. Discussion Elderly patients are considered a vulnerable population. The present study found that the main neoplasms associated with neurological manifestations are similar to the reported previously. We described the main symptoms that led to a neuro-oncological assessment. Moreover, we enlisted the final diagnoses made on elderly patients and compared them with others reports. To the best of our knowledge, this study provides valuable information, since there is scarce evidence in the literature about this topic. Conclusion Identifying the frequency and correlation of neurologic manifestations in older cancer patients will allow for the implementation of timely multidisciplinary care in an attempt to improve these patients’ health-related quality of life.