STEREOSPECIFIC SYNTHESIS OF OPTICALLY-ACTIVE 2-PHENYLSULFONYL-3-(1-HYDROXYETHYL)-4-AZETIDINONE - A PRECURSOR OF THIENAMYCIN-TYPE CARBAPENEMS

Stereospecific synthesis of optically active (2R,3S)-2-phenylsulfonyl-3-(1R-hydroxyethyl)-4-azetidinone from L-threonine is described. This compound is one of the key compounds for the synthesis of the thienamycin-type carbapenems.

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Bibliographic Details
Published inHeterocycles Vol. 24; no. 4; pp. 1007 - 1012
Main Authors SHIOZAKI, M, HIRAOKA, T, YANAGISAWA, H, MARUYAMA, H, KISHI, N, ODA, O
Format Journal Article
LanguageEnglish
Published Tokyo Japan Inst Heterocyclic Chemistry 01.04.1986
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Stereospecific synthesis of optically active (2R,3S)-2-phenylsulfonyl-3-(1R-hydroxyethyl)-4-azetidinone from L-threonine is described. This compound is one of the key compounds for the synthesis of the thienamycin-type carbapenems.
ISSN:0385-5414
1881-0942
DOI:10.3987/R-1986-04-1007