Efficient catalyst-free Domino approach for the synthesis of novel 2-benzazepine derivatives in water

A novel one-pot eco-friendly protocol for the synthesis of 2-benzazepine derivatives in water has been developed. 4-Chloro-3-formyl coumarin reacts with benzyl amines under catalyst-free conditions in aqueous medium to afford substituted 5-(2′-hydroxyaryl)-4-amido-2-benzazepines in excellent yields....

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Bibliographic Details
Published inTetrahedron letters Vol. 51; no. 23; pp. 3109 - 3111
Main Authors Venkata Prasad, J., Prabhakar, Maddela, Manjulatha, K., Rambabu, D., Anand Solomon, K., Gopi Krishna, G., Anil Kumar, K.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 09.06.2010
Elsevier
Subjects
Benzazepines
Benzyl amines
Catalyst-free
Chemistry
Chemistry, Organic
Coumarin
Green chemistry
One-pot synthesis
Physical Sciences
Scaffold hopping
Science & Technology
Scaffold hopping
One-pot synthesis
Benzazepines
Benzyl amines
Catalyst-free
Green chemistry
Coumarin
RING EXPANSION
SERIES
CROSS-COUPLING REACTIONS
IN-VITRO
INHIBITION
AZABENZOCYCLOHEPTENONES
CHEMISTRY
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Summary:A novel one-pot eco-friendly protocol for the synthesis of 2-benzazepine derivatives in water has been developed. 4-Chloro-3-formyl coumarin reacts with benzyl amines under catalyst-free conditions in aqueous medium to afford substituted 5-(2′-hydroxyaryl)-4-amido-2-benzazepines in excellent yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.04.020