TVT versus TOT, 2-year prospective randomized study

• Published in: World journal of urology Vol. 31; no. 3; pp. 645 - 649
• Main Authors: Wadie, Bassem S., Elhefnawy, Ahmed S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2013; Springer Nature B.V
• Subjects: Adult; Female; Follow-Up Studies; Gynecologic Surgical Procedures - methods; Humans; Incidence; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Oncology; Original Article; Outcome Assessment (Health Care); Postoperative Complications - epidemiology; Postoperative Complications - etiology; Suburethral Slings - adverse effects; Treatment Outcome; Urinary Incontinence, Stress - surgery; Urology; TOT; RCT; TVT; Outcome
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/s00345-012-0956-4

Purpose To evaluate in a comprehensive way TVT in comparison with TOT, the results of a single-center RCT are presented. Many studies addressed efficacy and safety of TVT and TOT. Methods Women included were adults having predominant SUI with positive stress test. They were randomized to get either TVT (Gynecare ® ) or TOT (Aris ® ). All women were seen 1 week, 3, 6, 12, 18, and 24 months. Results Seventy-one women completed 2-year follow-up. Median age was 47 (range 33–60 years). Mean ± SD BMI in TVT group was 34 ± 5 while in TOT group was 32 ± 5 kg/m 2 . POP of any degree was seen in 50 % (35 women). At 1 year, pad test–negative women were 31 and 29 for TVT and TOT, respectively. At 2 years, figures became 28 in TVT group and 27 in TOT. At 1 year, UDI 6 and IIQ 7 decreased by 78.5 and 81 % for TVT and by 69 % and 75 % for TOT group. At 2 year, comparable percentages were 73 and 79 % for TVT and 69 and 82 % for TOT. Fifteen unique patients had adverse events, 10 of them had TOT. Conclusions Both tapes have similar efficacy, regarding cure of incontinence. TVT is more effective, albeit insignificantly, than TOT at 2 years. However, serious adverse events were more frequent with TVT, yet TOT has more unique adverse events.