An efficient chiral synthesis of fluoro-containing amino acids: N-benzyloxycarbonyl-2-amino-4,4-difluorobutyric acid methyl ester and its analogs

Fluoro-containing amino acids, N-benzyloxycarbonyl-2-amino-4,4-difluorobutyric acid methyl ester and analogs, were prepared in high enantiomeric excess. Incorporation of 2-amino-4,4-difluoro butyric acid as P1 group provided a potent HCV NS3 protease inhibitor.

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Bibliographic Details
Published inTetrahedron letters Vol. 49; no. 5; pp. 901 - 902
Main Authors Hu, Zilun, Han, Wei
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.01.2008
Elsevier
Subjects
2-Amino-4,4-difluorobutyric acid
Chemistry
Chemistry, Organic
Fluoro amino acid
HCV protease inhibitor
Physical Sciences
Science & Technology
HCV protease inhibitor
Fluoro amino acid
2-Amino-4,4-difluorobutyric acid
fluoro amino acid
2-amino-4,4-difluorobutyric acid
DERIVATIVES
HCVNS3 PROTEASE INHIBITORS
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Summary:Fluoro-containing amino acids, N-benzyloxycarbonyl-2-amino-4,4-difluorobutyric acid methyl ester and analogs, were prepared in high enantiomeric excess. Incorporation of 2-amino-4,4-difluoro butyric acid as P1 group provided a potent HCV NS3 protease inhibitor.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.11.163