Genetics of Opiate Addiction

Addiction to MOP-r agonists such as heroin (and also addiction to prescription opioids) has reemerged as an epidemic in the twenty first century, causing massive morbidity. Understanding the genetics contributing to susceptibility to this disease is crucial for the identification of novel therapeuti...

Full description

Saved in:
Bibliographic Details
Published inCurrent psychiatry reports Vol. 16; no. 11; p. 504
Main Authors Reed, Brian, Butelman, Eduardo R., Yuferov, Vadim, Randesi, Matthew, Kreek, Mary Jeanne
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.11.2014
Springer Nature B.V
Subjects
Addictions
Genetic Disorders (W Berrettini
Heroin
Humans
Medicine
Medicine & Public Health
Methadone
Narcotics
Opioid-Related Disorders - drug therapy
Opioid-Related Disorders - genetics
Pharmacogenetics - methods
Psychiatry
Section Editor
Topical Collection on Genetic Disorders
Opiate
MOP-r
Addiction
SNP
Oxycodone
Dependence
Opioid
Association studies
Genetics
Prescription opioids
Heroin
Online AccessGet full text

Cover

More Information
Summary:Addiction to MOP-r agonists such as heroin (and also addiction to prescription opioids) has reemerged as an epidemic in the twenty first century, causing massive morbidity. Understanding the genetics contributing to susceptibility to this disease is crucial for the identification of novel therapeutic targets, and also for discovery of genetic markers which would indicate relative protection or vulnerability from addiction, and relative responsiveness to pharmacotherapy. This information could thus eventually inform clinical practice. In this review, we focus primarily on association studies of heroin and opiate addiction, and further describe the studies which have been replicated in this field, and are thus more likely to be useful for translational efforts.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-014-0504-6