Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice

• Published in: Nature (London) Vol. 353; no. 6341; pp. 260 - 262
• Main Authors: Garchon, Henri-Jean, Bedossa, Pierre, Eloy, Laure, Bach, Jean-Francois
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 19.09.1991
• Subjects: Alleles; Animals; Chromosome Mapping; Crosses, Genetic; Diabetes; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - pathology; Female; Genetic Linkage; Genetic Predisposition to Disease; Genetics; Genotype; Haplotypes; Insulin; Islets of Langerhans - pathology; Male; Medical research; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Obesity; Pancreatic Diseases - genetics; Pancreatic Diseases - pathology; Rodents; Salivary Gland Diseases - genetics; Salivary Gland Diseases - pathology
• ISSN: 0028-0836; 1476-4687
• DOI: 10.1038/353260a0

Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by autoimmune destruction of insulin-producing beta cells in the islets of Langerhans. Its onset is preceded by a long and variable period in which lymphoid cells infiltrate the pancreas but first remain outside the islets (peri-insulitis) before invading them (insulitis). Among susceptibility loci, only the major histocompatibility complex (MHC) has been clearly assigned. Genetic study of the nonobese diabetic (NOD) mouse model for insulin-dependent diabetes mellitus has revealed genetic linkage of insulitis and of early onset diabetes with two non-MHC loci mapping to chromosome 3 and 11 respectively. Here we report a close association of periinsulitis with a third non-MHC locus mapping to chromosome 1. Successive stages in the progression of diabetic disease thus appear to be controlled by distinct genes or sets of genes.