Variable Effects of Growth Factors on Developmental Gene Expression in Pancreatic Cancer Cells

• Published in: Doklady. Biochemistry and biophysics Vol. 481; no. 1; pp. 217 - 218
• Main Authors: Gnatenko, D. A., Kopantzev, E. P., Sverdlov, E. D.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.07.2018; Springer Nature B.V
• Subjects: Biochemistry; Biological and Medical Physics; Biomarkers, Tumor - genetics; Biomedical and Life Sciences; Biophysics; Carcinogenesis - drug effects; Carcinogenesis - genetics; Cell Line, Tumor; Embryogenesis; Embryonic growth stage; Fibroblast growth factor 1; Fibroblast growth factor 10; Fibroblast growth factor 2; Fibroblast growth factor 7; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Growth factors; Humans; Intercellular Signaling Peptides and Proteins - pharmacology; Life Sciences; Molecular Biology; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Sox9 protein; Transcription factors
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672918040105

Stimulation of BxPC-3, Panc-1, and MIA PaCA-2 pancreatic cancer cells with EGF, HGF, FGF-1, FGF-2, FGF-7, and FGF-10 growth factors caused changes in the expression of master genes regulating pancreatic development ( SOX9, HNF3b, GATA-4, GATA-6 , and HES1 ). This, in turn, caused changes in the expression profile of important transcription factors, embryonic development regulators. It was also found that the master genes belonging to the same family may cause opposite effects (suppression or enhancement of expression of a particular transcriptional regulator) in the same cell line.