Recent progress in asymmetric Biginelli reaction
The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1 )-ones) are interesting materials due to their significant pharmacologi...
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| Published in | Molecular diversity Vol. 17; no. 2; pp. 389 - 407 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.05.2013
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1381-1991 1573-501X 1573-501X |
| DOI | 10.1007/s11030-013-9439-9 |
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| Abstract | The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1
)-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction. |
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| AbstractList | The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1
)-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction. (ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image) The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1...)-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction.[PUBLICATION ABSTRACT] The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1H)-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction. The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1H)-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction.The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1H)-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction. |
| Author | Heravi, Majid M. Asadi, Shima Lashkariani, Boshra Malekzadeh |
| Author_xml | – sequence: 1 givenname: Majid M. surname: Heravi fullname: Heravi, Majid M. email: mmh1331@yahoo.com organization: Department of Chemistry, School of Sciences, Alzahra University – sequence: 2 givenname: Shima surname: Asadi fullname: Asadi, Shima organization: Department of Chemistry, School of Sciences, Alzahra University – sequence: 3 givenname: Boshra Malekzadeh surname: Lashkariani fullname: Lashkariani, Boshra Malekzadeh organization: Department of Chemistry, School of Sciences, Alzahra University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23588897$$D View this record in MEDLINE/PubMed |
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| Keywords | ones Dihydropyrimidin-2 Asymmetric synthesis Biginelli Multicomponent reactions (MCRs) |
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| Snippet | The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli... (ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image) The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea,... |
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| SubjectTerms | Acetoacetates - chemistry Aldehydes - chemistry Biochemistry Biomedical and Life Sciences Catalysis Life Sciences Organic Chemistry Pharmacy Polymer Sciences Pyrimidinones - chemical synthesis Short Review Stereoisomerism Urea - chemistry |
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| Title | Recent progress in asymmetric Biginelli reaction |
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