Recent progress in asymmetric Biginelli reaction

The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1 )-ones) are interesting materials due to their significant pharmacologi...

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Published inMolecular diversity Vol. 17; no. 2; pp. 389 - 407
Main Authors Heravi, Majid M., Asadi, Shima, Lashkariani, Boshra Malekzadeh
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.05.2013
Springer Nature B.V
Subjects
Acetoacetates - chemistry
Aldehydes - chemistry
Biochemistry
Biomedical and Life Sciences
Catalysis
Life Sciences
Organic Chemistry
Pharmacy
Polymer Sciences
Pyrimidinones - chemical synthesis
Short Review
Stereoisomerism
Urea - chemistry
ones
Dihydropyrimidin-2
Asymmetric synthesis
Biginelli
Multicomponent reactions (MCRs)
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Summary:The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1 )-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction.
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ISSN:1381-1991
1573-501X
1573-501X
DOI:10.1007/s11030-013-9439-9