An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

[Display omitted] An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides w...

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Bibliographic Details
Published inTetrahedron letters Vol. 46; no. 21; pp. 3751 - 3754
Main Authors Gelens, Edith, Smeets, Luc, Sliedregt, Leo A.J.M., van Steen, Bart J., Kruse, Chris G., Leurs, Rob, Orru, Romano V.A.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 23.05.2005
Elsevier
Subjects
Amides
Chemistry
Chemistry, Organic
Microwave
Physical Sciences
Science & Technology
Solvent free
Synthesis
Microwave
Amides
Synthesis
Solvent free
synthesis
solvent free
ORGANIC-SYNTHESIS
amides
AMINES
ACIDS
ALKYLATION
CHEMISTRY
microwave
PEPTIDE
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Summary:[Display omitted] An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.03.146